Low density lipoprotein receptor LDLR Rabbit Polyclonal Antibody | MédiMabs

Low density lipoprotein receptor LDLR Rabbit Polyclonal Antibody

Low density lipoprotein receptor LDLR Rabbit Polyclonal Antibody

Low density lipoprotein receptor LDLR Rabbit Polyclonal Antibody

MM-0198 -- anti-Low density lipoprotein receptor LDLR
$355.00/100 µl
QTY
For bulk pricing, please contact us.
Catalog Number : MM-0198
  • Product Name
    Low density lipoprotein receptor LDLR Rabbit Polyclonal Antibody
  • Host
    Rabbit
  • Clonality
    Polyclonal
  • Tested Applications
    WB
  • Application Notes
    Product description: A sensitive antibody against the C-terminal region of the LDLR.
  • Immunogen
    The antibody recognizes the c-terminal portion of LDLR
  • DataSHEET
  • Conjugation
    None
  • Reactivity
    Rat
  • Specificity
    C-terminal
  • Purification
    Non Purified
  • Target Name
    LDLR
  • Storage Buffer
    Lyophilized antibody can be kept at 4ºC for up to 3 months and should be kept at -20ºC for long-term storage
  • Alias
    LDLR, anti-LDLR
  • Format
    100 µl
  • Background
    The LDL Receptor (LDLR) is a transmembrane protein of 839 amino acids that mediates the endocytosis of cholesterol-rich LDL. The LDL receptor plays a critical role in cholesterol homeostasis. It binds, internalizes, and removes LDL from serum. LDLR recognizes the apoprotein B100 which is embedded in the phospholipid outer layer of LDL particles, as well as the apoE protein found in chylomicron remnants and VLDL remnants (IDL). To be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits (or buds) on the cell surface. Defects in LDLR are the cause of familial hypercholesterolemia, a common autosomal semi-dominant disease that affects about 1 in 500 individuals.

For laboratory research only, not for drug, diagnostic or other use.

  • References
    1. Ness, G.C., Kohlruss, N., and Gertz, K.R. (2003). Association of the low-density lipoprotein receptor with caveolae in hamster and rat liver. Biochem Biophys Res Commun 303, 177-181. 2. Ness, G.C., Lopez, D., Chambers, C.M., Zhao, Z., Beach, D.L., Ko, S.S., and Trzaskos, J.M. (1998). Effects of 15-oxa-32-vinyl-lanost-8-ene-3 beta,32 diol on the expression of 3-hydroxy-3-methylglutaryl coenzyme A reductase and low density lipoprotein receptor in rat liver. Arch Biochem Biophys 357, 259-264. 3. Ness, G.C., Zhao, Z., and Lopez, D. (1996). Inhibitors of cholesterol biosynthesis increase hepatic low-density lipoprotein receptor protein degradation. Arch Biochem Biophys 325, 242-248. 4. Ness, G.C., and Zhao, Z. (1994). Thyroid hormone rapidly induces hepatic LDL receptor mRNA levels in hypophysectomized rats. Arch Biochem Biophys 315, 199-202.
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