Free shipping on antibody orders delivered to Canada

Substance P Rat Monoclonal Antibody (NC1/34)

  • Home
  • /
  • Substance P Rat Monoclonal Antibody (NC1/34)
  • Alt

Substance P Rat Monoclonal Antibody (NC1/34)

SKU:
MM-0001-1

USD 355.00 /500 µL

Clonality: 
Monoclonal
Host: Rat
Reactivity: Human, predicted all mammals, crab, pigeons
Application: IHC, ICC, ELISA

QTY:

OVERVIEW

Target: 
Substance P
Target background: 
The discovery of substance P (SP) was reported in 1931. After more than 70 years of investigation, SP is perhaps the best understood neuropeptide transmitter. Substance P is an undecapeptide, which by the mid-1980s was recognized to belong to the tachykinin peptide family; it is also member of the neurokinins. It has been proposed that SP, released from primary afferent nerve endings, plays a role in chronic inflammation and pain. Neurotransmitters appear to play a key role in the regulation of emotions and antagonists of their receptors may be novel psychotropic drugs of the future.
Target alias: 
Substance P, tachykinin, neuropeptide, neurokinin, SP, anti-tachykinin, anti-neuropeptide, anti-neurokinin, anti-SP
Immunogen: 
Substance P
Specificity: This antibody recognizes the COOH-terminal end of substance P. It does not recognize Leu- or Met enkephalin, somatostatin or beta-endorphin; cross-reactivity with eledoisin: 5%. It recognizes Substance P in post-mortem tissue of the human brain.
Clone ID: 
NC1/34
Isotype: 
IgG2a
Preservative: 
None
Storage: 
Lyophilized antibody can be kept at 4ºC for up to 3 months and should be kept at -20ºC for long-term storage. To avoid freeze-thaw cycles, reconstituted antibody should be aliquoted before freezing for short-term storage (-20ºC) or for long-term storage (-80ºC). For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer.
Format: 
Lyophilized tissue culture supernatant
Recommend starting dilution: 
If reconstituted in 0.5 mL: IHC and ICC 1:200 - 1:500. Optimal dilution has to be determined by the user.
Limitations: 
Research Use Only