Chromogranin-A is a secreted protein known as a “prohormone” which is found in endocrine cells and neurons and may be released upon stimulation. It is thought to be involved in the formation of dense core granules, where it may be processed to form the bioactive peptide serpinin, which is thought to regulate the biogenesis of dense core granules in endocrine cells. Catestatin is a 21 amino acids fragment (352 to 372) from Chromogranin A. It's a bioactive peptide that can stimulate histamine release from mast cells and it's an inhibitor of catecholamines release. Catestatin has been shown to also have cardiovascular functions and antimicrobial activity.
Lyophilised purified in PBS pH7.4
Recommend starting dilution:
If reconstituted with deionized water in 25 µl: WB: 1:4000, IF: 1:500. Optimal dilution has to be determined by the user.
Lyophilized antibodies can be kept at 4ºC for up to 3 months and should be kept at -20ºC for long-term storage (2 years). To avoid freeze-thaw cycles, reconstituted antibodies should be aliquoted before freezing for long-term (1 year) storage (-80ºC) or kept at 4ºC for short-term usage (2 months). For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made with the assay buffer. After the maximum long-term storage period (2 years lyophilized or 1 year reconstituted) antibodies should be tested in your assay with a standard sample to verify if you have noticed any decrease in their efficacy.