Mouse anti-LLBmi1-1 (5C9) - Purified | FR | MédiMabs

Mouse anti-LLBmi1-1 (5C9) - Purified

Mouse anti-LLBmi1-1 (5C9) - Purified

Mouse anti-LLBmi1-1 (5C9) - Purified

MM-0253-P -- LLBmi1-1 (B lymphoma Mo-MLV insertion region 1 homolog) antibody Purified
$482,00/100 µg
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NUMÉRO : MM-0253-P
  • Nom du produit
    Mouse anti-LLBmi1-1 (5C9) - Purified
  • Serveur
    Mouse
  • Tested Applications
    ELISA, WB, CHIP,
  • Application Notes
    Optimal dilution has to be determined by the user.
  • Clone ID
    5C9
  • DataSHEET
  • Isotype
    IgG2b kappa
  • Reactivity
    A specific antibody against Bmi1-1.
  • Specificity
    Specific for: human and mouse; other species not tested.
  • Purification
    Purified
  • Target Name
    B lymphoma Mo-MLV insertion region 1 homolog)
  • Storage Buffer
    Lyophilized antibody can be kept at 4ºC for up to 3 months and should be kept at -20ºC for long-term storage.
  • Alias
    LLBmi1-1, B lymphoma Mo-MLV insertion region 1 homolog
  • Format
    100 µg
  • Background
    The polycomb group (PcG) of proteins contributes to the maintenance of cell identity, stem cell self-renewal, cell cycle regulation, and oncogenesis by maintaining the silenced state of genes that promote cell lineage specification, cell death, and cell-cycle arrest. Two complexes of PcG proteins cooperate to maintain long-term gene silencing through epigenetic chromatin modifications. The first complex, EED-EZH2, is recruited by DNA-binding transcription factors and the methylates histone H3 on Lys27 which facilitates the recruitment of the second complex, Polycomb group (PcG) multiprotein PRC1-like complex1 (PRC1). The PCR1 complex ubiquitinylates the histone H2A on Lys119. The Bmi1 protein, also known as Polycomb group RING finger protein 4 (Pcgf4) or RING finger protein 51 (Rnf51), is part of the PRC1 complex and acts to control axial skeleton development through Hox gene repression and regulation of p16 and p19, which are cell cycle inhibitor genes.

For laboratory research only, not for drug, diagnostic or other use.

  • References

    1. Courel, M., Friesenhahn, L., and Lees, J.A. (2008). E2f6 and Bmi1 Cooperate in Axial Skeletal Development Dev Dyn 237, 1232–1242.

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