Mouse anti-E2F4 Purified | FR | MédiMabs

Mouse anti-E2F4 Purified

Mouse anti-E2F4 Purified

Mouse anti-E2F4 Purified

MM-0252-P -- Mouse anti-Transcription factor E2F4 (LLF4.2) Purified,
$482,00/100 µg
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NUMÉRO : MM-0252-P
  • Nom du produit
    Mouse anti-E2F4 Purified
  • Serveur
    Mouse
  • Tested Applications
    WB, EMSA, IHC
  • Application Notes
    Optimal dilution has to be determined by the user.
  • Clone ID
    2.12E+08
  • DataSHEET
  • Isotype
    IgG1κ
  • Reactivity
    The antibody recognizes the human E2F4 protein.
  • Specificity
    Specific for: human, mouse; other species not tested.
  • Purification
    Purified
  • Target Name
    Transcription factor E2F4
  • Storage Buffer
    Lyophilized antibody can be kept at 4ºC for up to 3 months and should be kept at -20ºC for long-term storage.
  • Format
    100 µg
  • Background
    E2F are cellular transcription factors with essential role in the regulation of cell division. The members of the E2F family of proteins (a group of at least 8 related E2F proteins ) are major regulators of cell cycle entry, progression, and exit, they act as tumor suppressor proteins and are also a target of the transforming proteins of small DNA tumor viruses. Activity of the E2F proteins is tightly regulated by the physical association with three tumor suppressor proteins pRB, p107 and p130. Particularly, the transcription factor E2Ff4 acts in the regulation of cell cycle exit through its transcriptional repressive properties. E2F4 is regulated by interaction with RBL1 and RBL2. The transcription factor E2F4 is found in several cell types and is the most common E2F family member. Studies have demonstrated that E2F4 is involved in regulation of the thickness of the gut epithelium, decrease in maturation of hematopoietic cell types and an increased rate of apoptosis, suggesting that E2F4 plays a role in normal maturation of several cell types.

For laboratory research only, not for drug, diagnostic or other use.

  • References

    1. Danielian, P.S., Kim, C.F.B., Caron, A.M., Vasile, E., Bronson, R.T., and Lees, J.A. (2007). E2f4 is required for normal development of the airway epithelium. Dev Biol 305, 564–576.

    2. Humbert, P.O., Rogers, C., Ganiatsas, S., Landsberg, R.L., Trimarchi, J.M., Dandapani, S., Brugnara, C., Erdman, S., Schrenzel, M., Bronson, R.T., et al. (2000). E2F4 Is Essential for Normal Erythrocyte Maturation and Neonatal Viability. Mol Cell 6, 281–291.

    3. Kinross, K.M., Clark, A.J., Iazzolino, R.M., and Humbert, P.O. (2006). E2f4 regulates fetal erythropoiesis through the promotion of cellular proliferation. Blood 108, 886-895.

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