Human IgG / HRP Bispecific Monoclonal Antibody | FR | MédiMabs

Human IgG / HRP Bispecific Monoclonal Antibody

Human IgG / HRP Bispecific Monoclonal Antibody

Human IgG / HRP Bispecific Monoclonal Antibody

1014 -- Human IgG / HRP
$611,00/1 mL
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NUMÉRO : 1014
  • Nom du produit
    Human IgG / HRP Bispecific Monoclonal Antibody
  • Serveur
    Mouse / Mouse
  • Clonality
    Chimeric Monoclonal
  • Tested Applications
    ELISA
  • Application Notes
    This product is not recommended for use in IHC since excess HRP is present and will increase non-specific binding. Product # 1025 from our catalog is the same antibody prepared in the absence of HRP and is the preparation recommended for use in IHC.
  • Immunogen
    (A) human IgG and (B) Horseradish Peroxidase (HRP)
  • Modifications
    None
  • Clone ID
    McC2
  • DataSHEET
  • Isotype
    (A) IgG1 (B) IgG1
  • Conjugation
    None
  • Reactivity
    All Human IgG subtypes and recognizes the Fc portion of Human IgG. Also recognizes HRP types I, II, VI, IX and X
  • Specificity
    (A) all human IgG subtypes. Does not cross-react with human IgM or IgA or with bovine, mouse, rabbit or rat IgG. (B) Does not recognize HRP types VII, VIII, microperoxidase or crude HRP
  • Purification
    Non Purified
  • Target Name
    Human IgG and HRP
  • Storage Buffer
    Culture supernatant containing IgG fraction containing 600 purpurogallin units (or HRP/ml), sucrose, bovine serum albumin and thimerosal.
  • Format
    1 mL
  • Background
    This antibody is a bispecific monoclonal antibody capable of simultaneously recognize the horseradish peroxidase (HRP) and human IgG. This antibody has demonstrated its usefulness as a "universal developer" in a wide variety of immunobased techniques. Bi-specific monoclonal antibodies have been successfully used in one step immunocytochemistry and immuno-dot assays. These results demonstrated that bispecific antibodies can be applied in quick and simple staining procedures and provide intense immunostaining. The McC2 antibody was used for the detection of human IgG in a simple one step enzyme-linked immunosorbant assay (ELISA). Use of this bispecific antibody in this assay resulted in an excellent signal to noise ratio with background in negative control wells virtually nonexistent. McC2 was also applied in a clinical diagnostic test for the detection of auto anti-nuclear antibodies in patient sera.

For laboratory research only, not for drug, diagnostic or other use.

  • The production of a "universal developer" for the immunological detection of human IgG and its application in immunodiagnostics
  • Development of a mouse antiperoxidase secreting hybridoma for use in the production of a mouse PAP complex for immunocytochemistry and as a parent cell line in the development of hybrid hybridomas
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