TC-PTP (N term) Mouse Monoclonal Antibody - Purified | FR | MédiMabs

TC-PTP (N term) Mouse Monoclonal Antibody - Purified

TC-PTP (N term) Mouse Monoclonal Antibody - Purified

  • TC-PTP (N term) Mouse Monoclonal Antibody - Purified
  • TC-PTP (N term) Mouse Monoclonal Antibody - Purified

TC-PTP (N term) Mouse Monoclonal Antibody - Purified

MM-0018-P -- Purified T cell protein tyrosine phosphatase (TC-PTP) Mouse Monoclonal Antibody
$500,00/100 µg
QTY
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NUMÉRO : MM-0018-P
  • Nom du produit
    TC-PTP (N term) Mouse Monoclonal Antibody - Purified
  • Serveur
    Mouse
  • Clonality
    Monoclonal
  • Tested Applications
    Immunoprecipitation (IP), Western blot (WB)
  • Research Area(s)
    Signal Transduction, Cell Biology, Immunology, Cancer
  • Immunogen
    N-terminal fragment of TC-PTP
  • Modifications
    None
  • Clone ID
    3.00E+02
  • DataSHEET
  • Isotype
    IgG1
  • Conjugation
    None
  • Reactivity
    The antibody recognizes the N-terminal portion of TC-PTP; when used for Western blots the antibody detects one band in MEF cells extract, and 2 bands in spleen extract. The antibody recognizes 4 bands of TC-PTP from monkey
  • Specificity
    mouse, rat, human and monkey
  • Purification
    Protein G
  • Target Name
    T cell protein tyrosine phosphatase
  • Storage Buffer
    PBS
  • Alias
    Protein-tyrosine phosphatase PTP-2 MPTP Ptpn2 Ptpt
  • Format
    100 µg
  • Background
    The protein tyrosine phosphatase (PTP) belongs to a large family of enzymes involved in the regulation of cellular signaling and homeostasis, each possessing a 240 amino acid PTP domain. The T-cell protein tyrosine phosphatase (TC-PTP) is predominantly expressed in the hematopoietic lineage. TC-PTP null mice suffer severe defects in the hematopoietic compartment and die at 3-5 weeks of age from severe anemia. TC-PTP -/- murine embryonic fibroblasts have a slow progression through the G1 phase of the cell cycle and have compromised NF-B activation. JAK 1 and 3 have been identified as physiological substrates of TC-PTP. Recent genetic studies have revealed an association between the PTPN2 (TC-PTP) gene and diseases like type 1 diabetes and Crohn’s disease.

For laboratory research only, not for drug, diagnostic or other use.

  • Murine embryonic fibroblasts lacking TC-PTP display delayed G1 phase through defective NF-kappaB activation
  • High-fat-fed obese glutathione peroxidase 1-deficient mice exhibit defective insulin secretion but protection from hepatic steatosis and liver damage
  • Characterization of PTPN2 and its use as a biomarker
  • Deletion of the protein tyrosine phosphatase gene PTPN2 in T-cell acute lymphoblastic leukemia.
  • Murine embryonic fibroblasts lacking TC-PTP display delayed G1 phase through defective NF-kappaB activation
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