Tau cleaved by caspase-6 Rabbit Polyclonal Antibody | FR | MédiMabs

Tau cleaved by caspase-6 Rabbit Polyclonal Antibody

Tau cleaved by caspase-6 Rabbit Polyclonal Antibody

Tau cleaved by caspase-6 Rabbit Polyclonal Antibody

MM-0141 -- anti-Tau cleaved by caspase-6
$355,00/50 µl
QTY
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NUMÉRO : MM-0141
  • Nom du produit
    Tau cleaved by caspase-6 Rabbit Polyclonal Antibody
  • Serveur
    Rabbit
  • Clonality
    Polyclonal
  • Tested Applications
    WB,IP,IHC
  • DataSHEET
  • Conjugation
    None
  • Reactivity
    Human
  • Specificity
    KSPVVSGD
  • Purification
    Non Purified
  • Target Name
    Tau cleaved by caspase-6
  • Alias
    anti-Tau cleaved by caspase-6
  • Format
    50 µl
  • Background
    The Tau protein is a microtubule-associated protein mainly expressed in neurons and plays a crucial role in the neuronal cytoskeleton stabilization. They are abundant in neurons of the central nervous system and are less common elsewhere, but are also expressed at very low levels in CNS astrocytes and oligodendrocytes. Defects in tau proteins can result in dementias, such as Alzheimer's disease (AD). AD is a neurodegenerative pathology which is characterized by the presence of two types of neuropathological hallmarks: neurofibrillary tangles (NFTs) and senile plaques (SPs). NFTs are intraneuronal aggregations mainly composed of abnormally phosphorylated Tau. In neuropil threads (NPTs), NFTs, and neuritic plaques (NPs) of severe Alzheimer’s disease (AD) brains highly abundant amounts of active Caspase 6 and Tau cleaved by Caspase 6 (TauΔCsp6) have been found. Caspases are a family of cytosolic aspartate-specific cysteine proteases. Sequential activation of caspases plays a central role in the execution phase of cell apoptosis. Caspase 6 has been associated to increase levels of β-amyloid peptide in primary cultures of human neurons. Caspase 6 has also been demonstrated to be active in NPTs, NFTs, and NPs in the hippocampus and temporal cortex in sporadic AD. Caspase 6 activation has been suggested to be an early event in AD and to precede the development of frank lesions. The main role of tau proteins is to stabilize microtubules. Tau proteins can be mainly found in neurons, in the central nervous system.

For laboratory research only, not for drug, diagnostic or other use.

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