Anti-SUMO-2/3 (8A2) | FR | MédiMabs

Anti-SUMO-2/3 (8A2)

Anti-SUMO-2/3 (8A2)

  • Anti-SUMO-2/3 (8A2)
  • Anti-SUMO-2/3 (8A2)

Anti-SUMO-2/3 (8A2)

MM-0203 -- Anti-SUMO-2/3 (8A2) Mouse Monoclonal antibody
$355,00/100 µg
QTY
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NUMÉRO : MM-0203
  • Nom du produit
    Anti-SUMO-2/3 (8A2)
  • Serveur
    Mouse
  • Tested Applications
    WB, IF
  • Application Notes
    1:1000 for WB; 1:2000 for IF. Optimal dilution has to be determined by the user.
  • Clone ID
    8A2
  • DataSHEET
  • Isotype
    IgG
  • Reactivity
    The antibody recognizes SUMO-2 and SUMO-3, but shows no detectable cross reactivity with SUMO-1
  • Specificity
    mouse, rat, hamster, bovine.
  • Format
    100 µg
  • Background
    By post-translational covalent conjugation to other proteins within the cell, small ubiquitinrelated modifiers (SUMOs) are able to regulate the cell-cycle through a common enzyme cascade involving the same E1 activating and E2 conjugating enzymes. In vertebrates, three SUMO proteins have been identified: SUMO-1, and the highly similar SUMO-2 and SUMO-3 (often referred to as SUMO-2/3). Comparably, one SUMO protein is expressed by invertebrates. Post-translational modifications by SUMO are thought to regulate multiple processes, including transcription, subcellular protein localization, and the stability of proteins.

For laboratory research only, not for drug, diagnostic or other use.

  • References

    1. Zhang X, Goeres J, Zhang H, Yen T, Porter A, Matunis M. SUMO-2/3 modification and binding regulate the association of CENP-E with kinetochores and progression through mitosis. Mol Cell, 29(6):729-41, 2008.

    2. Verger A, Perdomo J, Crossley M. Modification with SUMO. A role in transcriptional regulation. EMBO Rep, 4(2):137-42, 2003.

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