SCL/TAL1-N Mouse Monoclonal Antibody (1E6) - Purified | FR | MédiMabs

SCL/TAL1-N Mouse Monoclonal Antibody (1E6) - Purified

SCL/TAL1-N Mouse Monoclonal Antibody (1E6) - Purified

SCL/TAL1-N Mouse Monoclonal Antibody (1E6) - Purified

MM-0213-P -- anti-SCL/TAL1 protein
$482,00/100 µg
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NUMÉRO : MM-0213-P
  • Nom du produit
    SCL/TAL1-N Mouse Monoclonal Antibody (1E6) - Purified
  • Serveur
    Mouse
  • Clonality
    Monoclonal
  • Tested Applications
    WB
  • Clone ID
    1E6
  • DataSHEET
  • Isotype
    IgG1
  • Conjugation
    None
  • Reactivity
    Mouse
  • Specificity
    N-terminal
  • Purification
    Purified
  • Target Name
    SCL/TAL1
  • Format
    100 µg
  • Background
    The stem cell leukemia (SCL) protein (also known as T cell Acute Lymphocytic Leukemia 1 Protein (TAL1)) is a hematopoietic-specific transcription factor of the basic helix-loop-helix (bHLH) family. SCL is expressed in hematopoietic stem cells, as well as multipotent, erythroid, and megakaryocytic progenitors; it is essential for the regulation of hematopoiesis and also regulates angiogenesis and erythrocyte maturation. In patients with T-cell acute lymphoblastic leukemia (T-ALL), the SCL gene is the most frequent target of chromosomal rearrangements with an irregular activation of this transcription factor involved in 60% of T-ALL cases, which indicates that abnormal regulation of SCL’s activity may lead to the development of T cell leukemia.

For laboratory research only, not for drug, diagnostic or other use.

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