Anti-RPTPsigma Mouse Monoclonal Antibody | FR | MédiMabs

Anti-RPTPsigma Mouse Monoclonal Antibody

Anti-RPTPsigma Mouse Monoclonal Antibody

  • Anti-RPTPsigma Mouse Monoclonal Antibody
  • Anti-RPTPsigma Mouse Monoclonal Antibody
  • Anti-RPTPsigma Mouse Monoclonal Antibody

Anti-RPTPsigma Mouse Monoclonal Antibody

MM-0020 -- Receptor protein tyrosine phosphatase sigma (RPTPs) Mouse Monoclonal Antibody
$393,00/100 µg
Pour les prix de gros, nous contacter.
NUMÉRO : MM-0020
  • Nom du produit
    Anti-RPTPsigma Mouse Monoclonal Antibody
  • Serveur
  • Clonality
  • Tested Applications
    Immunohistochemistry (IHC), Immunoprecipitation (IP), Western blot (WB)
  • Research Area(s)
    Signal Transduction, Cell Biology, Immunology, Cancer
  • Immunogen
    recombinant protein corresponding to the intracellular domain of mouse RPTP .
  • Modifications
  • Clone ID
  • DataSHEET
  • Isotype
    IgG1 Kappa chain
  • Conjugation
  • Reactivity
    The antibody recognizes the intracellular sub-unit of RPTPσ.
  • Specificity
    Human, Mouse and Monkey
  • Purification
    Non Purified
  • Target Name
    Receptor protein tyrosine phosphatase sigma
  • Storage Buffer
    Tissue culture supernatant
  • Alias
    R-PTP-S PTPNU-3 Receptor-type tyrosine-protein phosphatase sigma R-PTP-sigma Ptprs
  • Format
    100 µg
  • Background
    Type IIa receptor protein tyrosine phosphatases (RPTPs) are a group of well-characterized proteins that are involved in axon growth and guidance during neural development. Members of this subfamily, RPTPσ, RPTP and LAR contain two cytoplasmic phosphatase domains and extracellular immunoglobulin domains followed by fibronectin type III repeats. RPTPσ is a type I transmembrane protein that has an apparent molecular weight of approximately 80 kDa. It is highly expressed by neurons in developing and adult mammalian nervous system. Knock-out mice for RPTPσ show growth retardation, delayed peripheral nerve development and high mortality rates. The role of RPTPσ in axon guidance during development suggests it could influence axon regeneration after injury in the adult mouse. It has been shown that RPTPσ slows axon regeneration in the adult injured CNS.

For laboratory research only, not for drug, diagnostic or other use.

  • Splicing-Dependent Trans-synaptic SALM3-LAR-RPTP Interactions Regulate Excitatory Synapse Development and Locomotion.
  • Chondroitin sulfate proteoglycans down-regulate spine formation in cortical neurons by targeting tropomyosin-related kinase B (TrkB) protein
  • Postsynaptic TrkC and presynaptic PTPσ function as a bidirectional excitatory synaptic organizing complex
  • Receptor protein tyrosine phosphatase sigma inhibits axonal regeneration and the rate of axon extension
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