Phospho Prion Protein (pPrP Ser43) Rabbit Polyclonal Antibody | FR | MédiMabs

Phospho Prion Protein (pPrP Ser43) Rabbit Polyclonal Antibody

Phospho Prion Protein (pPrP Ser43) Rabbit Polyclonal Antibody

Phospho Prion Protein (pPrP Ser43) Rabbit Polyclonal Antibody

MM-0112 -- anti-Phospho Prion Protein (Ser43)
$355,00/50 µl
QTY
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NUMÉRO : MM-0112
  • Nom du produit
    Phospho Prion Protein (pPrP Ser43) Rabbit Polyclonal Antibody
  • Serveur
    Rabbit
  • Clonality
    Polyclonal
  • Tested Applications
    ELISA,WB,IP,IHC
  • DataSHEET
  • Conjugation
    None
  • Reactivity
    Mammals
  • Purification
    Non purified
  • Target Name
    Phosphorylated Prion Protein
  • Alias
    anti-Phospho Prion Protein, anti-Prion Protein
  • Format
    50 µl
  • Background
    Prion related neurodegenerative diseases, called transmissible spongiform encephalopathies, are observed in many animal species. These diseases involve conversion of normal cellular prion protein (PrPc) into a form that is insoluble and resistant to proteases (PrPSc). The protease resistant form can polymerize into fibrils which accumulate in infected tissues and cause cell death and tissue damage. PrPs have an N-terminal signal sequence and a C-terminal linkage to glycosylphosphatidylinositol anchor. The mature protein is a glycosylated protein that associates with cell membranes. Phosphorylation of PrPC at Ser-43 by Cdk5 promotes proteinase K resistance, prion aggregation, and fibril formation in vitro. In addition, Ser-43 phosphorylation is upregulated in scrapie-infected mouse brain relative to controls. Thus, phosphorylation of Ser-43 may be an important mechanism leading conversion of PrPc to PrPSc and the onset of disease. The antibody was raised against Phospho Prion Protein (pPrP Ser43).

For laboratory research only, not for drug, diagnostic or other use.

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