Huntingtin-Interacting Protein 1, HIP1 Rabbit Polyclonal Antibody - Purified | FR | MédiMabs

Huntingtin-Interacting Protein 1, HIP1 Rabbit Polyclonal Antibody - Purified

Huntingtin-Interacting Protein 1, HIP1 Rabbit Polyclonal Antibody - Purified

Huntingtin-Interacting Protein 1, HIP1 Rabbit Polyclonal Antibody - Purified

MM-0031 -- anti-HIP1
$355,00/100 µl
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NUMÉRO : MM-0031
  • Nom du produit
    Huntingtin-Interacting Protein 1, HIP1 Rabbit Polyclonal Antibody - Purified
  • Serveur
    Rabbit
  • Clonality
    Polyclonal
  • Tested Applications
    Western blot (WB), Immunofluorescence (IF)
  • Research Area(s)
    Neuroscience, Cancer
  • Modifications
    None
  • DataSHEET
  • Conjugation
    None
  • Reactivity
    The antibody recognizes C-terminus of human HIP1
  • Specificity
    Human, Rat
  • Purification
    Purified
  • Target Name
    Huntingtin-Interacting Protein 1,
  • Storage Buffer
    PBS
  • Alias
    HIP1
  • Format
    100 µl
  • Background
    Hungtinton’s disease (HD) is an inherited neurodegenerative disorder characterized by the expression of an expanded polyglutamine tract in the protein huntingtin. HIP1 (huntingtin interacting protein 1) binds to normal huntingtin but this interaction is lost in HD. HIP1 also binds to components of clathrin-coated pits and vesicles and is a marker of clathrin-coated membranes. HIP1 expression levels are altered in several types of cancer.

For laboratory research only, not for drug, diagnostic or other use.

  • Huntingtin-interacting protein 1 is overexpressed in prostate and colon cancer and is critical for cellular survival
  • An actin-binding protein of the Sla2/Huntingtin interacting protein 1 family is a novel component of clathrin-coated pits and vesicles
  • HIP1, a human homologue of S. cerevisiae Sla2p, interacts with membrane-associated huntingtin in the brain
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