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CD44 role in T cell extravasation to inflammation site and cancer metastatic potential.

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May 09th 2019 - Custom companion diagnostic

 

Custom companion diagnostic, a must in drug development

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A team led by Dr. Chomont, had recently published an article in PLOS pathogens (Pardons, M et al 2019) where they have developed a flow cytometry approach, named HIV-flow, in order to evaluate the diversity in the phenotypes of HIV-infected cells. They have based their approach on detecting p24 positive cells.

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Questions, background research, hypothesis, experiments, data analysis, conclusions, repeat. 

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A recent publication shows that for a second time a patient was “cured” by a bone-marrow transplant. The donor had two copies of a mutation in the CCR5 gene (CD195 or C-C chemokine receptor type 5), which gives people resistance to HIV infection. For 18 month now, the patient was able to stop taking antiretroviral drugs with no detectable viral loads. This is incredibly good news however this kind of treatment wouldn’t be suitable for most people with HIV.

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MediMabs would like to congratulate for their recent publication (Pozzi et al. 2019 JCI) and highlight the work of Dr. Julien, Dr. Gravel and Dr.Kriz groups from the CERVO brain research center of Université Laval, and is also proud of being part of this project with our modest contribution.

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February 13th 2019 - Valentine's day dimers
January 31st 2019 - Which FGFR isoform drives cancer?



The promise of FGFR inhibitors in the clinic, but which FGFR isoform drives cancer?

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January 31st 2019 - Happy new year and MIMs meeting

Another great occasion to discuss about immunology in Montreal organized by the (Montreal Immunology Meeting) MIM committee. We hope to meet you there at the next meetings on March 20th and May 8th if you are in the Montreal area. For more detail on the event or the MIM, please visit their website.

MédiMabs is a proud sponsor of the 5à7 meeting of the MIM. An occasion for immunologist to listen to great speakers and discuss together.

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