PACT Rabbit Polyclonal Antibody - Purified | MédiMabs

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PACT Rabbit Polyclonal Antibody - Purified

PACT Rabbit Polyclonal Antibody  - Purified

  • PACT Rabbit Polyclonal Antibody  - Purified
  • PACT Rabbit Polyclonal Antibody  - Purified

PACT Rabbit Polyclonal Antibody - Purified

MM-0228-P -- anti-PACT
$482.00/50 µg

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QTY
  • Product Name
    PACT Rabbit Polyclonal Antibody - Purified
  • Host
    Rabbit
  • Clonality
    Polyclonal
  • DataSHEET
  • Conjugation
    None
  • Reactivity
    Human, mouse
  • Specificity
    Full length
  • Purification
    Affinity Purified
  • Storage Buffer
    Lyophilized antibody can be kept at 4ºC for up to 3 months and should be kept at -20ºC for long-term storage.
  • Format
    50 µg
  • Background
    The Interferon-inducible double stranded RNA-dependent protein kinase activator, also known as PKR-associated protein X (RAX in mouse) or PACT (in human) is a cellular protein that heterodimerizes with PKR through its double-stranded RNA binding proteins (dsRBDs). PKR is an interferon (IFN)-induced serine-threonine protein kinase that plays a central role in IFN's antiviral and antiproliferative activities. In the absence of viral infections, PACT activates PKR in response to diverse stress signals as serum starvation and treatments with arsenite or peroxide, resulting in the induction of the apoptotic cascade. PACT is expressed in most cell types at a very low abundance, and overexpression of PACT causes PKR activation, leading to eIF2α± phosphorylation. PACT has been shown to interact with another DRBM-containing protein, TRBP (TAR RNA binding protein), and form a triple complex with Dicer to facilitate the production of siRNA.

For laboratory research only, not for drug, diagnostic or other use.

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