Ubiquitinated H2B Mouse Monoclonal Antibody - Purified | MédiMabs

Ubiquitinated H2B Mouse Monoclonal Antibody - Purified

Ubiquitinated H2B Mouse Monoclonal Antibody - Purified

  • Ubiquitinated H2B Mouse Monoclonal Antibody - Purified

Ubiquitinated H2B Mouse Monoclonal Antibody - Purified

MM-0029 -- anti-Ubiquitinated H2B
$393.00/100 µg
QTY
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Catalog Number : MM-0029
  • Product Name
    Ubiquitinated H2B Mouse Monoclonal Antibody - Purified
  • Host
    Mouse
  • Clonality
    Monoclonal
  • Tested Applications
    Western blot (WB), chromatin IP (ChIP), Immunofluorescece (IF), Immunohistochemistry (IHC)
  • Research Area(s)
    Epigenetics & Nucleas Signaling
  • Application Notes
    If reconstituted in 100 µl: WB 2-3 µg/ml; ChIP 3-5 µg per sample; IHC: 1:200 – 1:500. Optimal dilution has to be determined by the user.
  • Immunogen
    Branched peptide corresponding to the conjugation site of ubiquitin on human histone H2B
  • Modifications
    None
  • Clone ID
    NRO3
  • DataSHEET
  • Isotype
    IgG2a
  • Conjugation
    None
  • Reactivity
    Human, Mouse, Drosophila, Arabidopsis
  • Specificity
    The antibody recognizes the K120 ubiquitination of the human histone H2B with no detectable cross-reactivity with either non-ubiquitinated H2B or ubiquitinated
  • Purification
    Protein G
  • Target Name
    Ubiquitinated Histone H2B
  • Storage Buffer
    PBS
  • Alias
    Ubiquitinated Histone H2B, Ubiquitin Histone H2B, H2B, ub histone h2b, ub h2b
  • Format
    100 µg
  • Background
    It has been demonstrated that histone modifications are implicated in the regulation of transcription. Recent studies have revealed complex links between H2B ubiquitination and the control of transcription. Some studies suggest that H2B ubiquitination plays a role in transcriptional silencing whereas others suggest a role in transcriptional initiation and elongation. *Product previously referred to as MM-0029-P

For laboratory research only, not for drug, diagnostic or other use.

  • Microarray Analysis Reveals Potential Biological Functions of Histone H2B Monoubiquitination
  • Gonadotropin gene transcription is activated by menin-mediated effects on the chromatin
  • Invadolysin acts genetically via the SAGA complex to modulate chromosome structure
  • Involvement of histone H2B monoubiquitination in the regulation of mouse preimplantation development
  • The ubiquitin-selective chaperone Cdc48/p97 associates with Ubx3 to modulate monoubiquitylation of histone H2B
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$393.00

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