Anti-TC-PTP (C term) Mouse Monoclonal Antibody - Purified | MédiMabs

Anti-TC-PTP (C term) Mouse Monoclonal Antibody - Purified

Anti-TC-PTP (C term) Mouse Monoclonal Antibody - Purified

  • Anti-TC-PTP (C term) Mouse Monoclonal Antibody - Purified
  • Anti-TC-PTP (C term) Mouse Monoclonal Antibody - Purified

Anti-TC-PTP (C term) Mouse Monoclonal Antibody - Purified

MM-0019-P -- Purified T cell protein tyrosine phosphatase (TC-PTP) Mouse Monoclonal Antibody
$500.00/100 µg
QTY
For bulk pricing, please contact us.
Catalog Number : MM-0019-P
  • Product Name
    Anti-TC-PTP (C term) Mouse Monoclonal Antibody - Purified
  • Host
    Mouse
  • Clonality
    Monoclonal
  • Tested Applications
    Immunoprecipitation (IP), Western blot (WB)
  • Research Area(s)
    Signal Transduction, Cell Biology, Immunology, Cancer
  • Immunogen
    C-terminal fragment of TC-PTP
  • Modifications
    None
  • Clone ID
    6F3
  • DataSHEET
  • Isotype
    IgG1
  • Conjugation
    None
  • Reactivity
    The antibody recognizes the C-terminal portion of TC-PTP.
  • Specificity
    mouse and rat
  • Purification
    Protein G
  • Target Name
    T cell protein tyrosine phosphatase
  • Storage Buffer
    PBS
  • Alias
    Protein-tyrosine phosphatase PTP-2 MPTP Ptpn2 Ptpt
  • Format
    100 µg
  • Background
    The protein tyrosine phosphatase (PTP) belongs to a large family of enzymes involved in the regulation of cellular signaling and homeostasis, each possessing a 240 amino acid PTP domain. The T-cell protein tyrosine phosphatase (TC-PTP) is predominantly expressed in the hematopoietic lineage. TC-PTP null mice suffer severe defects in the hematopoietic compartment and die at 3-5 weeks of age from severe anemia. TC-PTP -/- murine embryonic fibroblasts have a slow progression through the G1 phase of the cell cycle and have compromised NF-B activation. JAK 1 and 3 have been identified as physiological substrates of TC-PTP. Recent genetic studies have revealed an association between the PTPN2 (TC-PTP) gene and diseases like type 1 diabetes and Crohn’s disease.

For laboratory research only, not for drug, diagnostic or other use.

  • PTPN2-deficiency exacerbates T follicular helper cell and B cell responses and promotes the development of autoimmunity
  • Leptin and insulin act on POMC neurons to promote the browning of white fat
  • The adaptor TRAF3 restrains the lineage determination of thymic regulatory T cells by modulating signaling via the receptor for IL-2
  • TCPTP regulates SFK and STAT3 signaling and is lost in triple-negative breast cancers
  • T cell protein tyrosine phosphatase (TCPTP) deficiency in muscle does not alter insulin signalling and glucose homeostasis in mice
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$500.00

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