Substance P Rat Monoclonal Antibody | MédiMabs

Substance P Rat Monoclonal Antibody

Substance P Rat Monoclonal Antibody

Substance P Rat Monoclonal Antibody

1021 -- Substance P
$355.00/0.5 mL
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Catalog Number : 1021
  • Product Name
    Substance P Rat Monoclonal Antibody
  • Host
    Rat-mouse hybrid
  • Clonality
    Monoclonal
  • Tested Applications
    IHC,ICC, Neuroimmunocytotoxic studies.
  • Research Area(s)
    Neuroscience, Cancer, Metabolism
  • Immunogen
    Substance P
  • Modifications
    None
  • Clone ID
    NC1/34
  • DataSHEET
  • Isotype
    IgG2a
  • Conjugation
    None
  • Reactivity
    This antibody recognizes the COOH-terminal end of substance P. It does not recognize Leu- or Met enkephalin, somatostatin or beta-endorphin; cross-reactivity with eledoisin: 5%. It recognizes Substance P in postmortem tissue of the human brain.
  • Specificity
    predicted all mammals, crab, pigeons
  • Purification
    Non Purified
  • Target Name
    Substance P
  • Storage Buffer
    Tissue culture supernatant containing 0.05% thimerosal
  • Alias
    anti-Substance P, tachykinin, neuropeptide, neurokinin, SP, anti-tachykinin, anti-neuropeptide, anti-neurokinin, anti-SP
  • Format
    0.5 mL
  • Background
    The discovery of substance P (SP) was reported in 1931. After more than 70 years of investigation, SP is perhaps the best understood neuropeptide transmitter. Substance P is an undecapeptide, which by the mid-1980s was recognized to belong to the tachykinin peptide family; it is also member of the neurokinins. It has been proposed that SP, released from primary afferent nerve endings, plays a role in chronic inflammation and pain. Neurotransmitters appear to play a key role in the regulation of emotions and antagonists of their receptors may be novel psychotropic drugs of the future.

For laboratory research only, not for drug, diagnostic or other use.

  • Parasympathetic nerve fibers invade the upper dermis following sensory denervation of the rat lower lip skin
  • Skin blood vessels are simultaneously innervated by sensory, sympathetic and parasympathetic fibers
  • Organization of substance P primary sensory neurons: ultrastructural and physiological correlates
  • Detection of substance P in the central nervous system by a monoclonal antibody
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$355.00

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