Misfolded Human SOD1 Mouse Monoclonal Antibody - Purified | MédiMabs

Misfolded Human SOD1 Mouse Monoclonal Antibody - Purified

Misfolded Human SOD1 Mouse Monoclonal Antibody - Purified

  • Misfolded Human SOD1 Mouse Monoclonal Antibody - Purified

Misfolded Human SOD1 Mouse Monoclonal Antibody - Purified

MM-0070-2-P -- anti-Misfolded Human SOD1
$500.00/200 µl
QTY
For bulk pricing, please contact us.
Catalog Number : MM-0070-2-P
  • Product Name
    Misfolded Human SOD1 Mouse Monoclonal Antibody - Purified
  • Host
    Mouse
  • Clonality
    Monoclonal
  • Tested Applications
    Western Blot (WB), Immunoprecipitation (IP), Immunohistochemistry (IHC), Immunofluorescence (IF)
  • Research Area(s)
    Neuroscience, Signal Transduction, Cell Biology, Cancer, Metabolism
  • Immunogen
    Recombinant human SOD1 G93A APO
  • Modifications
    None
  • Clone ID
    C4F6
  • DataSHEET
  • Isotype
    IgG2a
  • Conjugation
    None
  • Reactivity
    The antibody recognizes misfolded forms of mutant human SOD1 protein. IF: WT, G93A, G85R, G127X, G37R and A4V; WB (denatured): WT, G93A, D90A, G37R and A4V; WB (native): G93A; IHC: WT, G93A and G37R, IP: G93A.
  • Specificity
    Human
  • Purification
    Protein G
  • Target Name
    human SOD1 mutant protein
  • Storage Buffer
    PBS
  • Alias
    Superoxide dismutase [Cu-Zn], Superoxide dismutase 1, hSOD1, SOD1
  • Format
    200 µl
  • Background
    Superoxide dismutase 1 (SOD1) is a soluble cytoplasmic and mitochondrial intermembrane space protein. SOD1 binds copper and zinc ions and is one of three isozymes responsible for destroying free superoxide radicals in the body. Mutations in SOD1 cause familial amyotrophic lateral sclerosis type 1 (ALS1). These mutations have been linked to accumulation of harmful superoxide radicals, promotion of apoptosis, formation of aggregates of misfolded superoxide dismutase which are toxic and the continued stimulation of nerve cells that causes them to burn out and die.

For laboratory research only, not for drug, diagnostic or other use.

  • Mahogunin ring finger 1 confers cytoprotection against mutant SOD1 aggresomes and is defective in an ALS mouse model
  • Morpholino-mediated SOD1 reduction ameliorates an amyotrophic lateral sclerosis disease phenotype
  • Adverse Effects of a Sod1-Peptide Immunotherapy on Sod1g93a Mouse Slow Model of Amyotrophic Lateral Sclerosis
  • Substantially elevating the levels of αB-crystallin in spinal motor neurons of mutant SOD1 mice does not significantly delay paralysis or attenuate mutant protein aggregation
  • Oral Treatment with CuII(atsm) Increases Mutant SOD1 In Vivo but Protects Motor Neurons and Improves the Phenotype of a Transgenic Mouse Model of Amyotrophic Lateral Sclerosis
Average Rating :
0 Based on 0 rating
Be the first to review this product Write a Review

  • 5 Star
     0
  • 4 Star
     0
  • 3 Star
     0
  • 2 Star
     0
  • 1 Star
     0

Have you used this product?

Rate this product :

$500.00

Consult a Scientist