STAM Mouse Monoclonal Antibody (G1G5) - Purified | MédiMabs

STAM Mouse Monoclonal Antibody (G1G5) - Purified

STAM Mouse Monoclonal Antibody (G1G5) - Purified

  • STAM Mouse Monoclonal Antibody (G1G5) - Purified
  • STAM Mouse Monoclonal Antibody (G1G5) - Purified
  • STAM Mouse Monoclonal Antibody (G1G5) - Purified

STAM Mouse Monoclonal Antibody (G1G5) - Purified

MM-0225-P -- anti-STAM
$482.00/50 µg
QTY
For bulk pricing, please contact us.
Catalog Number : MM-0225-P
  • Product Name
    STAM Mouse Monoclonal Antibody (G1G5) - Purified
  • Host
    Mouse
  • Clonality
    Monoclonal
  • Tested Applications
    WB, IHC
  • Clone ID
    G1G5
  • DataSHEET
  • Isotype
    IgG1
  • Conjugation
    None
  • Reactivity
    Mouse, rat, human
  • Specificity
    Full length
  • Purification
    Purified
  • Target Name
    STAM2
  • Format
    50 µg
  • Background
    The signal transducing adapter molecule 1 (STAM1) and signal transducing adapter molecule 2 (STAM2) are regulators of receptor signalling and trafficking. STAM interacts with the hepatocyte growth factorregulated tyrosine kinase substrate (Hrs) to form a heterodimeric complex which mediates the endocytic sorting of ubiquitinated membrane proteins. Studies have demonstrated that the complex STAM/Hrs is tyrosine-phosphorylated in response to a variety of growth factors including EGF, HGF and PDGF. STAM1 and STAM2 phosphorylation occurs on tyrosines upon stimulation with cytokines through the Jak3 signaling pathway, which is essential for T-cell development. STAM has an important role in T-cell development and survival in the thymus through the prevention of apoptosis but is not necessary for the proximal signaling of TCR and cytokine receptors.

For laboratory research only, not for drug, diagnostic or other use.

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$482.00

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