Presenilin 2 Mouse Monoclonal Antibody | MédiMabs

Presenilin 2 Mouse Monoclonal Antibody

Presenilin 2 Mouse Monoclonal Antibody

Presenilin 2 Mouse Monoclonal Antibody

MM-0023 -- anti-Presenilin 2
$355.00/250 µg
QTY
For bulk pricing, please contact us.
Catalog Number : MM-0023
  • Product Name
    Presenilin 2 Mouse Monoclonal Antibody
  • Host
    Mouse
  • Clonality
    Monoclonal
  • Tested Applications
    Western Blot (WB), Immunofluorescence (IF), ELISA
  • Research Area(s)
    Neuroscience, Cancer, Metabolism, Signal Transduction
  • Immunogen
    Pepitde corresponding to aa 34-45 of Presenilin 2
  • Modifications
    None
  • Clone ID
    APS21
  • DataSHEET
  • Isotype
    IgG1
  • Conjugation
    None
  • Reactivity
    The antibody recognizes the C-terminal region of the Presenilin 2 (amino acids 34-45) with no cross-reactivity observed with Presenilin 1
  • Specificity
    Human, Mouse, Rat
  • Purification
    Non Purified
  • Target Name
    Presenilin 2
  • Storage Buffer
    Protein free tissue culture supernatant
  • Alias
    PS-2, AD3LP, AD5, E5-1, STM-2, PSEN2
  • Format
    250 µg
  • Background
    Presenilin is an integral membrane protein ubiquitously expressed in the brain; it is mainly expressed in neurons where it is localized in the endoplasmic reticulum. Mutations in the presenilin proteins (PSEN1; PSEN2) are linked to an inherited form of Alzheimer's disease in some patients by increasing the production of the longer form of amyloid-beta. Presenilins are thought to affect gamma-secretase by regulating amyloid precursor protein (APP) processing and cleavage of the Notch receptor.

For laboratory research only, not for drug, diagnostic or other use.

  • Analysis Of Presenilin 1 And Presenilin 2 Expression And Processing By Newly Developed Monoclonal Antibodies
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