Presenilin 1 Mouse Monoclonal Antibody | MédiMabs

Presenilin 1 Mouse Monoclonal Antibody

Presenilin 1 Mouse Monoclonal Antibody

Presenilin 1 Mouse Monoclonal Antibody

MM-0022 -- anti-Presenilin 1
$355.00/250 µg
QTY
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Catalog Number : MM-0022
  • Product Name
    Presenilin 1 Mouse Monoclonal Antibody
  • Host
    Mouse
  • Clonality
    Monoclonal
  • Tested Applications
    Western Blot (WB), Immunofluorescence (IF), ELISA
  • Research Area(s)
    Neuroscience, Cancer, Metabolism, Signal Transduction
  • Immunogen
    Pepitde corresponding to aa 313-334 of Presenilin 1
  • Modifications
    None
  • Clone ID
    APS18
  • DataSHEET
  • Isotype
    IgG1
  • Conjugation
    None
  • Reactivity
    The antibody recognizes the N-terminal region of the Presenilin 1 (amino acids 313-334) with no cross-reactivity observed with Presenilin 2
  • Specificity
    Human, Mouse, Rat
  • Purification
    Non Purified
  • Target Name
    Presenilin 1
  • Storage Buffer
    Protein free tissue culture supernatant
  • Alias
    antiPS-1, Protein S182, PSEN1
  • Format
    250 µg
  • Background
    Presenilin is an integral membrane protein ubiquitously expressed in the brain; it is mainly expressed in neurons where it is localized in the endoplasmic reticulum. Mutations in the presenilin proteins (PSEN1; PSEN2) are linked to an inherited form of Alzheimer's disease in some patients by increasing the production of the longer form of amyloid-beta. Presenilins are thought to affect gamma-secretase by regulating amyloid precursor protein (APP) processing and cleavage of the Notch receptor.

For laboratory research only, not for drug, diagnostic or other use.

  • Analysis Of Presenilin 1 And Presenilin 2 Expression And Processing By Newly Developed Monoclonal Antibodies
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