Misfolded Human SOD1 Mouse Monoclonal Antibody - Purified | MédiMabs

Misfolded Human SOD1 Mouse Monoclonal Antibody - Purified

Misfolded Human SOD1 Mouse Monoclonal Antibody - Purified

  • Misfolded Human SOD1 Mouse Monoclonal Antibody - Purified

Misfolded Human SOD1 Mouse Monoclonal Antibody - Purified

MM-0070-P -- Misfolded Human SOD1
$500.00/200 µl
QTY
For bulk pricing, please contact us.
Catalog Number : MM-0070-P
  • Product Name
    Misfolded Human SOD1 Mouse Monoclonal Antibody - Purified
  • Host
    Mouse
  • Clonality
    Monoclonal
  • Tested Applications
    Western Blot (WB), Immunoprecipitation (IP), Immunohistochemistry (IHC), Immunofluorescence (IF)
  • Research Area(s)
    Neuroscience, Signal Transduction, Cell Biology, Cancer, Metabolism
  • Immunogen
    Recombinant human SOD1 G93A APO
  • Modifications
    None
  • Clone ID
    B8H10
  • DataSHEET
  • Isotype
    IgG1
  • Conjugation
    None
  • Reactivity
    The antibody recognizes misfolded forms of mutant human SOD1 protein. IP: wt, G93A, D90A, G85R, G127X, and G37R; WB (denatured): wt, D90A, G85R, G127X and G37R; WB (native): G93A; IF: G93A, G85R, G127X and G37R; Flow Cytometry: G93A.
  • Specificity
    Human
  • Purification
    Protein G
  • Target Name
    human SOD1 mutant protein
  • Storage Buffer
    PBS
  • Alias
    Superoxide dismutase [Cu-Zn], Superoxide dismutase 1, hSOD1, SOD1
  • Format
    200 µl
  • Background
    Superoxide dismutase 1 (SOD1) is a soluble cytoplasmic and mitochondrial intermembrane space protein. SOD1 binds copper and zinc ions and is one of three isozymes responsible for destroying free superoxide radicals in the body. Mutations in SOD1 cause familial amyotrophic lateral sclerosis type 1 (ALS1). These mutations have been linked to accumulation of harmful superoxide radicals, promotion of apoptosis, formation of aggregates of misfolded superoxide dismutase which are toxic and the continued stimulation of nerve cells that causes them to burn out and die.

For laboratory research only, not for drug, diagnostic or other use.

  • In vivo kinetic approach reveals slow SOD1 turnover in the CNS
  • A Chemical Chaperone-Based Drug Candidate is Effective in a Mouse Model of Amyotrophic Lateral Sclerosis (ALS)
  • Intracerebroventricular infusion of monoclonal antibody or its derived Fab fragment against misfolded forms of SOD1 mutant delays mortality in a mouse model of ALS
  • Endogenous macrophage migration inhibitory factor reduces the accumulation and toxicity of misfolded SOD1 in a mouse model of ALS
  • Morpholino-mediated SOD1 reduction ameliorates an amyotrophic lateral sclerosis disease phenotype
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$500.00

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