Human Hace1 Mouse Monoclonal Antibody - Purified | MédiMabs

Human Hace1 Mouse Monoclonal Antibody - Purified

Human Hace1 Mouse Monoclonal Antibody - Purified

Human Hace1 Mouse Monoclonal Antibody - Purified

MM-0066-P -- anti-Human Hace1
$482.00/100 µg
QTY
For bulk pricing, please contact us.
Catalog Number : MM-0066-P
  • Product Name
    Human Hace1 Mouse Monoclonal Antibody - Purified
  • Host
    Mouse
  • Clonality
    Monoclonal
  • Tested Applications
    Western blot (WB), ELISA (E), Immunofluorescence (IF), Immunohistochemistry-P (IHC-P).
  • Research Area(s)
    Cell Biology, Epigenetics & Nulcear Signaling, Cancer
  • Immunogen
    Full Length HACE 1
  • Modifications
    None
  • Clone ID
    8D3
  • DataSHEET
  • Isotype
    IgG
  • Conjugation
    None
  • Reactivity
    The antibody recognizes the human HACE1 protein
  • Specificity
    Human
  • Purification
    Purified
  • Target Name
    E3 ubiquitin-protein ligase HACE1
  • Storage Buffer
    PBS
  • Alias
    E3 ubiquitin-protein ligase HACE1, HECT domain and ankyrin repeat-containing, E3 ubiquitin-protein ligase 1, HECT-type E3 ubiquitin transferase, HACE1, KIAA1320
  • Format
    100 µg
  • Background
    HACE 1 (HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1) is an ubiquitin ligase with six N-terminal ankyrin and a C-terminal HECT domain. HACE 1 is ubiquitously expressed in normal tissues and is frequently downregulated in human tumors. HACE 1 has been reported to act as a tumor suppressor through a phosphorylation-dependent degradation of cyclin D1. HACE1 has also been shown to bind GTP-bound Rac1 (Ras-related C3 botulinum toxin substrate 1) and to catalyze its polyubiquitination. HACE1 expression increases the ubiquitination of Rac1 when the GTPase is activated. HACE1 is required for cytotoxic necrosis factor 1 (CNSF1)-mediated depletion of Rac1 and efficient invasion of endothelial cell monolayer by bacteria, which suggests a role for HACE1 in host defense against pathogens. More recently, HACE1 was reported to target the Golgi membrane through interactions with Rab proteins. During mitotic Golgi disassembly, the ubiquitin ligase activity of HACE1 is required for subsequent post-mitotic Golgi membrane fusion.

For laboratory research only, not for drug, diagnostic or other use.

  • The E3 ligase HACE1 is a critical chromosome 6q21 tumor suppressor involved in multiple cancers
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