Huntingtin-Interacting Protein 1-Related, HIP1R Rabbit Polyclonal Antibody | MédiMabs

Huntingtin-Interacting Protein 1-Related, HIP1R Rabbit Polyclonal Antibody

Huntingtin-Interacting Protein 1-Related, HIP1R Rabbit Polyclonal Antibody

Huntingtin-Interacting Protein 1-Related, HIP1R Rabbit Polyclonal Antibody

MM-0032 -- anti-HIP1R
$355.00/100 µl
QTY
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Catalog Number : MM-0032
  • Product Name
    Huntingtin-Interacting Protein 1-Related, HIP1R Rabbit Polyclonal Antibody
  • Host
    Rabbit
  • Clonality
    Polyclonal
  • Tested Applications
    Western blot (WB), Immunofluorescence (IF)
  • Research Area(s)
    Neuroscience, Cancer
  • Immunogen
    aa 1049-1068
  • DataSHEET
  • Conjugation
    None
  • Reactivity
    The antibody recognizes the C-terminus of the human HIP1R
  • Specificity
    Human, Rat
  • Purification
    Protein G
  • Target Name
    Huntingtin-Interacting Protein 1-Related
  • Storage Buffer
    PBS
  • Alias
    HIP1-related protein, Huntingtin-interacting protein 12, HIP-12, HIP1R
  • Format
    100 µl
  • Background
    HIP1R (huntingtin interacting protein 1 related) was first cloned based on its sequence similarity with HIP1 (Huntingtin Interacting Protein 1). HIP1 binds to normal huntingtin but this interaction is lost in Huntington’s disease (HD). HIP1 also binds to components of clathrin-coated pits and vesicles and is a marker of clathrin-coated membranes. HIP1R colocalizes with and binds to actin and this interaction may link the endocytic machinery to the actin cytoskeletal dynamic processes.

For laboratory research only, not for drug, diagnostic or other use.

  • An actin-binding protein of the Sla2/Huntingtin interacting protein 1 family is a novel component of clathrin-coated pits and vesicles
  • Clathrin light chains function in mannose phosphate receptor trafficking via regulation of actin assembly
  • Cloning, expression analysis, and chromosomal localization of HIP1R, an isolog of huntingtin interacting protein (HIP1)
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