Cruciform DNA Mouse Monoclonal Antibody - Purified | MédiMabs

Cruciform DNA Mouse Monoclonal Antibody - Purified

Cruciform DNA Mouse Monoclonal Antibody - Purified

Cruciform DNA Mouse Monoclonal Antibody - Purified

MM-0027-P -- anti-Cruciform DNA
$500.00/100 µg
QTY
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Catalog Number : MM-0027-P
  • Product Name
    Cruciform DNA Mouse Monoclonal Antibody - Purified
  • Host
    Mouse
  • Clonality
    Monoclonal
  • Tested Applications
    Electrophoretic Mobility Shift Assay (EMSA), Western blot (WB). Immunofluorescence (IF)
  • Research Area(s)
    Epigenetics & Nucleas Signaling
  • Immunogen
    heteroduplex (cruciform) DNA
  • Modifications
    n
  • Clone ID
    2D3
  • DataSHEET
  • Isotype
    IgG1
  • Conjugation
    None
  • Reactivity
    The antibody recognizes the stem loop structure of Cruciform DNA
  • Specificity
    Cruciform DNA
  • Purification
    Purified
  • Target Name
    Cruciform DNA
  • Storage Buffer
    PBS
  • Alias
    Cruciform DNA, Heteroduplex DNA
  • Format
    100 µg
  • Background
    Inverted repeat sequences are known to form cruciform structures in negatively supercoiled DNA. They are widespread in the genomes of both eukaryotes and prokaryotes, occurring more often than expected among random sequences. In some bacteria, extrusion of cruciform DNA is required for initiation of replication and transcription, though certain inverted repeat sequences are unstable when subcloned into bacteria. Because such structures might impair DNA replication fidelity, the role of inverted repeats in mutagenesis and in human diseases has been widely studied.

For laboratory research only, not for drug, diagnostic or other use.

  • Superhelical DNA as a preferential binding target of 14-3-3γ protein
  • Slipped (CTG)•(CAG) Repeats of the Myotonic Dystrophy Locus: Surface Probing with Anti-DNA Antibodies
  • The 14-3-3 Protein Homologues from Saccharomyces cerevisiae, Bmh1p and Bmh2p, Have Cruciform DNA-binding Activity and Associate in Vivo with ARS307
  • Cruciform-extruding regulatory element controls cell-specific activity of the tyrosine hydroxylase gene promoter
  • Characterization of the Binding Specificity of Two Anticruciform DNA Monoclonal Antibodies
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