Clathrin Light Chain, CLCa / CLCb Rabbit Polyclonal Antibody | MédiMabs

Clathrin Light Chain, CLCa / CLCb Rabbit Polyclonal Antibody

Clathrin Light Chain, CLCa / CLCb Rabbit Polyclonal Antibody

Clathrin Light Chain, CLCa / CLCb Rabbit Polyclonal Antibody

MM-0033 -- anti-Clathrin Light Chain, CLCa / CLCb
$355.00/200 µl
QTY
For bulk pricing, please contact us.
Catalog Number : MM-0033
  • Product Name
    Clathrin Light Chain, CLCa / CLCb Rabbit Polyclonal Antibody
  • Host
    Rabbit
  • Clonality
    Polyclonal
  • Tested Applications
    Western blot (WB), Immunofluorescence (IF), ELISA (E)
  • Research Area(s)
    Neuroscience, Cancer
  • Immunogen
    aa 27-49
  • Modifications
    None
  • DataSHEET
  • Conjugation
    None
  • Reactivity
    The antibody recognizes the N-terminal of human CLC isoforms CLCa and CLCb (aa 27-49)
  • Specificity
    Human, Mouse, Rat
  • Purification
    Non Purified
  • Target Name
    Clathrin Light Chain CLCa / CLCb
  • Storage Buffer
    Whole Serum
  • Alias
    Clathrin Light Chain CLCa / CLCb, CLCa, CLCb
  • Format
    200 µl
  • Background
    Clathrin-coated vesicles (CCVs) are the major carriers for uptake of nutrients and signalling receptors and for the reformation of synaptic vesicles. Pathogens co-opt the endocytic pathway to gain access into cells. Clathrin is the major component of CCVs and is composed of clathrin-heavy chain and clathrin-light chain (CLC). CLC is a reliable marker of clathrin-coated structures and is also used as a marker of the presynaptic nerve terminal in neurons. Both CLCa and CLCb have alternatively spliced isoforms that are differentially expressed in tissues.

For laboratory research only, not for drug, diagnostic or other use.

  • Clathrin light chains function in mannose phosphate receptor trafficking via regulation of actin assembly.
  • Cell- and stimulus-dependent heterogeneity of synaptic vesicle endocytic recycling mechanisms revealed by studies of dynamin 1-null neurons
  • Connecdenn, A Novel DENN Domain-Containing Protein of Neuronal Clathrin-Coated Vesicles Functioning in Synaptic Vesicle Endocytosis
  • Non-stoichiometric relationship between clathrin heavy and light chains revealed by quantitative comparative proteomics of clathrin-coated vesicles from brain and liver.
  • Clathrin self-assembly is regulated by three light-chain residues controlling the formation of critical salt bridges
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$355.00

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