Amyloid precursor protein cleaved by caspase-6 Rabbit Polyclonal Antibody | MédiMabs

Amyloid precursor protein cleaved by caspase-6 Rabbit Polyclonal Antibody

Amyloid precursor protein cleaved by caspase-6 Rabbit Polyclonal Antibody

Amyloid precursor protein cleaved by caspase-6 Rabbit Polyclonal Antibody

MM-0142 -- anti-Amyloid precursor protein cleaved by caspase-6
$355.00/50 µl
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Catalog Number : MM-0142
  • Product Name
    Amyloid precursor protein cleaved by caspase-6 Rabbit Polyclonal Antibody
  • Host
    Rabbit
  • Clonality
    Polyclonal
  • Tested Applications
    WB
  • DataSHEET
  • Conjugation
    None
  • Reactivity
    Human
  • Specificity
    ISEVKMD
  • Purification
    Non Purified
  • Target Name
    Amyloid precursor protein cleaved by caspase-6
  • Alias
    anti-Amyloid precursor protein cleaved by caspase-6
  • Format
    50 µl
  • Background
    Amyloid precursor protein (APP) functions as a cell surface receptor in the synapses of neurons and is implicated in neurite growth, neuronal adhesion, axonogenesis and cell mobility. APP is known as the precursor molecule whose proteolysis generates beta amyloid (Aβ). Defects in APP are the causes of Alzheimer’s disease type 1 and of amyloidosis cerebroarterial. Caspase activation has been found to have a central role in neuronal death and chronic neurodegenerations such as Huntington’s, Parkinson’s and Alzheimer’s diseases. Proteolytic cleavage of specific substrates has also been demonstrated to be an important cellular event in the pathogenesis of AD and inhibition of cleavage of APP by caspase-6 was demonstrated to suppress synapse loss, dentate gyral atrophy, and memory loss.

For laboratory research only, not for drug, diagnostic or other use.

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$355.00

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