MédiMabs Clones
A blog about science
Beyond Irreversibility: Restoring the Brain’s Recycling Fleet to Combat Alzheimer’s Disease
While prior studies report NAD+ depletion in Alzheimer’s disease (AD) models and partial attenuation of pathology with NAD+ precursor supplementation (1), the “more is better” approach has its limits. High doses of NAD+ precursors can produce supraphysiologic levels that may promote cancer, making them a risky long-term solution. In a recent study in Cell Reports […]
When Brain Beavers Build Too Big: Breaking the Glycogen Dam in Tauopathy
In the complex landscape of neurodegenerative disorders like Alzheimer’s disease and frontotemporal lobar degeneration (FTLD), an interesting case of metabolic misbehavior has been identified by a research team at the Buck Institute of Research on Aging (1). Think of glycogen, the brain’s emergency energy reserve, as the building material. In affected neurons, the tau protein […]
hnRNP A1: The nuclear DJ fine-tuning antiviral immunity
In the cell’s nuclear control room, RNA-binding proteins (RBPs) are the DJs of gene expression. In a new study, Deshaies et al. (1) explore two isoforms of hnRNP A1 (A1 and A1B members of the hnRNP family) involved in RNA splicing, transport, and metabolism. While both isoforms are structurally similar and co-expressed across tissues, they […]
